Description: 

ATX-GD-59 is an admixture of two soluble, synthetic peptides based on the sequence of the human TSHR that have been shown to function as apitopes in HLA-DR3 transgenic mice immunized with human TSHR (18). One peptide, 9B-N (15 amino-acid residues), is an exact sequence found in TSHR, whereas the other, 5D-K1 (21 amino-acid residues), contains an amino-acid sequence found in the TSHR with the addition and replacement of charged amino acids to the N- and C-terminal flanks for increased solubility. Both peptides overlap with residues previously documented as TSHR immunodominant T-cell epitopes in HLA-transgenic murine models of GD (19,20). ATX-GD-59 is thought to bind with high affinity to HLA-DR molecules on the surface of immature dendritic cells in the draining lymph node without prior internalization, thereby reducing the risk for activation of antigen-presenting cells

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